SSRIs Given During Pregnancy May Cause Withdrawal Symptoms in the Neonate
http://www.medscape.com/viewarticle/498763"Selective serotonin reuptake inhibitors (SSRIs) given during pregnancy may lead to withdrawal symptoms in the neonate, according to the results of a database analysis published in the Feb. 5 issue of The Lancet.
"SSRIs have been associated with withdrawal symptoms," write Emilio J. Sanz, from the University of La Laguna in Spain, and colleagues. "Neonatal withdrawal syndrome associated with SSRIs — characterised by convulsions, irritability, abnormal crying, and tremor — has been reported in several cases."
Using the data mining method routinely used to screen the World Health Organization database of adverse drug reactions, the investigators identified an association between paroxetine and neonatal convulsions in December 2001. They then used an information component (IC) measure to screen for unexpected adverse reactions relative to information contained in the database, and they evaluated cases of neonatal convulsions and neonatal withdrawal syndrome associated with drugs included in the anatomical therapeutic chemical groups N06AB and N06AX.
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Other links with longer write-ups on this story:
Anti-depressants pregnancy riskhttp://news.bbc.co.uk/1/hi/health/4229851.stmAntidepressants Linked to Withdrawals in Newborns, Study Sayshttp://www.bloomberg.com/apps/news?pid=10000103&sid=aaWQez5K8H1g&refer=usNewborns at Risk of Antidepressant Withdrawal, Study Sayshttp://www.washingtonpost.com/wp-dyn/articles/A63188-2005Feb4.html