...that are still not understood. In the first place, the rate of human infection is quite high relative to previous reports for
S. suis:
Streptococcus suis, an important pathogen of pigs, is endemic in most pig-rearing countries of the world, including the UK. The organism is carried in the tonsils of pigs, and pig-to-pig spread is mainly by nose-to-nose contact or by aerosol over short distances. Human infection with Streptococcus suis is rarely reported and only about 150 cases have been reported from the world literature. Two serotypes have been implicated in human infections; S. suis type 2, an established zoonotic human pathogen and more recently S. suis type 14. Human infection may be severe, with meningitis, septicaemia, endocarditis, and deafness. People in direct contact with pigs or pig products are considered at risk. Asplenic patients are known to be at greater risk from the disease. Human infection is thought to occur mainly via cuts or abrasions when handling infected carcasses.
Maybe a new serotype?
S. suis vaccine has been tested, although it's efficacy uncertain as far as I'm aware:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=226975&tools=botAn autogenous vaccine was developed, using sonicated bacteria, with a strain of Streptococcus suis capsular type 1/2. The objectives of this study were to evaluate the antibody response following vaccination and to assess the changes in antibody levels in pigs from a herd showing clinical signs of S. suis capsular type 1/2 infection in 6- to 8-week-old pigs. An enzyme-linked immunosorbent assay using the vaccine antigen was standardized. Results from a preliminary study involving 2 control and 4 vaccinated 4-week-old pigs indicated that all vaccinated pigs produced antibodies against 2 proteins of 34 and 43 kDa, respectively, and, in 3 out of 4 vaccinated pigs, against the 117-kDa muramidase-released protein. For the serologic profile, groups of 30 pigs from the infected herd were blood sampled at 2, 4, 6, 8, and 10 weeks of age. The lowest antibody level was observed between weeks 6 and 8, presumably corresponding to a decrease in maternal immunity. A marked increase was seen at 10 weeks of age, shortly after the onset of clinical signs in the herd. For the vaccination field trial, newly weaned, one-week-old piglets were divided into 2 groups of 200 piglets each (control and vaccinated); blood samples were collected from 36 piglets in each group at 2-week intervals for 12 weeks. A significant increase (P 0.05) in antibody response was observed 4 weeks following vaccination and the level of antibodies stayed high until the end of the experiment. In the control group, the increase was only observed at 13 weeks of age, probably in response to a natural infection. The response to the vaccine varied considerably among pigs and was attributed, in part, to the levels of maternal antibodies at the time of vaccination. No outbreak of S. suis was observed in the control or vaccinated groups, so the protection conferred by the vaccine could not be evaluated.
on edit-- it appears that there are at least 35 serotypes of
S. suis out there, and that the likelihood of a commercial vaccine is low because the antigen site is unknown. An autogenous vaccine for the specific serotype in this zoonotic outbreak is at least theoretically feasible, however (for pigs).