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US NewsMosquito-borne disease kills nearly 1 million people, mostly African children, every yearMONDAY, Dec. 8 (HealthDay News) Results from two phase II trials in Africa show that a new malaria vaccine is effective at preventing both infection and the mosquito-borne disease itself in infants and children. "Malaria is killing almost 1 million people, mostly African children, every year," Dr. Christian Loucq, director of the PATH Malaria Vaccine Initiative, said during a morning teleconference Monday. "Clearly, the world needs a safe and effective malaria vaccine."
The vaccine, called RTS,S, is one of several vaccine candidates for malaria, Loucq said. Other vaccines are under development, but RTS,S is the one that is furthest along and ready for phase III testing, he noted. "These studies offer further evidence that RTS,S provides both infants and young children with substantial protection against the disease," Loucq said. "We are closer than ever before to having a malaria vaccine for use by the children in Africa."
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"There was a 65 percent reduction in first infection from malaria in those infants who received three doses of the vaccine and were followed over a six-month period," said lead researcher Dr. Salim Abdulla, head of the Bagamoyo Research and Training Centre of the Ifakara Health Institute, in Tanzania. "A safe and efficacious malaria vaccine for children in Africa may be available in the near future and have the potential of alleviating a huge burden of malaria disease," he added.
The findings were published online Dec. 8 in the New England Journal of Medicine.
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http://health.usnews.com/articles/health/healthday/2008/12/08/malaria-vaccine-effective-in-latest-trials.html
One of medicine's Holy Grail's.
The NEJM articles are currently free online:
Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Agehttp://content.nejm.org/cgi/content/full/NEJMoa0807381Safety and Immunogenicity of RTS,S/AS02D Malaria Vaccine in Infantshttp://content.nejm.org/cgi/content/full/NEJMoa0807773