The truth about depression.

[HysteryDiagnosis]

What some people who sell the "other" stuff, that is now causing Lilly great concern... may not want you to know. To know is good, to be kept in the dark about the role of DHA and other essential fats in autoimmune disease, how well the cellular sodium pump works, depression, schizophrenia is to be a pawn of corporate America, a rube, a mark, a lab rat.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15172679
1: Prostaglandins Leukot Essent Fatty Acids. 2004 Jul;71(1):13-8. Related Articles, Links
Click here to read
In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide.

De Vriese SR, Christophe AB, Maes M.
Department of Internal Medicine, Division of Nutrition, Ghent University Hospital, Belgium.
BACKGROUND: Depression is accompanied by a depletion of n-3 poly-unsaturated fatty acids (PUFAs). There is also a negative correlation between suicide and fish-oil intake (rich in n-3 PUFAs) across different countries. Both depression and suicide show a seasonal variation and are related to disorders in the serotonergic system. AIMS: The present study was carried out to determine if there is a seasonal variation in the PUFA fractions in serum phospholipids and whether there are significant relationships between lowered n-3 PUFA status and the seasonal variation in the number of suicide deaths and serotonergic markers of suicide. METHODS: We took monthly blood samples during 1 calendar year from 23 healthy volunteers and analyzed the PUFA composition in serum phospholipids and related those data to the annual variation in the mean weekly number of suicides for Belgium and the Bmax <3H>-paroxetine binding to platelets in the same 23 subjects. RESULTS: Significant annual rhythms were detected in the long-chain PUFAs only, i.e. arachidonic acid (C20: 4n-6; AA), eicosapentaenoic acid (C20: 5n-3; EPA), and docosahexaenoic acid (C22: 6n-3; DHA). There was a significant correlation between the changes over the last 2 weeks in AA and EPA and the mean weekly number of violent, but not nonviolent, suicide deaths in Belgium. There was a significant correlation between the PUFAs, AA and DHA, and the Bmax <3H>-paroxetine binding to platelets. CONCLUSIONS: Our results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA. The results suggest that the seasonality in PUFAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex. Copyright 2004 Elsevier Ltd.

PMID: 15172679

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15279495
1: Naliwaiko K, Araujo RL, da Fonseca RV, Castilho JC, Andreatini R, Bellissimo MI, Oliveira BH, Martins EF, Curi R, Fernandes LC, Ferraz AC. Related Articles, Links
Abstract Effects of fish oil on the central nervous system: a new potential antidepressant?
Nutr Neurosci. 2004 Apr;7(2):91-9.
PMID: 15279495

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15110732
5: Frasure-Smith N, Lesperance F, Julien P. Related Articles, Links
Abstract Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes.
Biol Psychiatry. 2004 May 1;55(9):891-6.
PMID: 15110732

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15023646
8: Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM. Related Articles, Links
Abstract Docosahexaenoic acid and post-partum depression - is there a link?
Asia Pac J Clin Nutr. 2003;12 Suppl:S37.
PMID: 15023646

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14610651
Turner N, Else PL, Hulbert AJ. Related Articles, Links
Abstract Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism.
Naturwissenschaften. 2003 Nov;90(11):521-3. Epub 2003 Oct 10.
PMID: 14610651

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12640327
12: Colin A, Reggers J, Castronovo V, Ansseau M. Related Articles, Links
Abstract
Encephale. 2003 Jan-Feb;29(1):49-58. Review. French.
PMID: 12640327

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12480795
13: Simopoulos AP. Related Articles, Links
Free Full Text Omega-3 fatty acids in inflammation and autoimmune diseases.
J Am Coll Nutr. 2002 Dec;21(6):495-505. Review.
PMID: 12480795

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12103448
15: Hibbeln JR. Related Articles, Links
Abstract Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis.
J Affect Disord. 2002 May;69(1-3):15-29.
PMID: 12103448

[purduejake]

1. Thanks for the link...

My doctors recommend it as well. I believe flax seed oil is almost as good for people who don't eat stuff from animals.

[gumby]

2. Are you suggesting that fish oil would be a good

addition to everyone's daily diet?

[HysteryDiagnosis]

7. Are you suggesting that fish oil would be a good

addition to everyone's daily diet?<<

I am suggesting that far far too many Americans on a low seafood/low omega three fat diet, far too rich in vegetable oil diet are on anti-depressants.

I am suggesting that many of the "diseases" that docs label us with are addressable by correcting imbalances.

I am suggesting that we are not told the truth.

I am suggesting that many people are hooked up on medications of mass destruction who don't need to be.

I am suggesting that there is often a better way.

What I know is that my daily diet contains a glucosamine/chondroitin/omega three, six, nine, DHA supplement blend.

What I know is that I have regained the smarts and balance I lost as a young man.

What I am telling you is that the many are poisoned and put in harms way by those whom they trust for lack of knowledge.

The people who have tried to keep this knowledge hush hush in the medical community should be tried for crimes against humanity.

Maybe I went a little overboard there... but then, that is what I am good at. :)

It's been a long hard road from North Collins New York... how I do miss it.... sorry for rambling... hope you get the message herein. EOM

[MuseRider]

3. Thanks for the links.

Lots to read. I have been taking fish oil for quite a while and it has been recommended by my rheumatologist that I keep taking it to help with my RA. Thanks.

[HysteryDiagnosis]

6. I keep taking it to help with my RA. Thanks.

Is that all you are taking for your RA?? There is a bounty of safe and I mean safe additional articles available such as tumeric (in capsule form) curcumin (in capsule form) green lipped mussel, pine bark extract, glucosamine and chondroitin sulfate etc. There are some great formulas out there that incorporate many if not all of these.

Glad you are doing the fish oil thing however, remember, in an uncontrolled inflammatory state you want to adjust the ratio of your omega threes to your omega 6's. You want to bring them more in balance so do read up on that. You may want to make sure that you are not taking a mix with 6's as well. I see that you mention fish oil so I imagine you are just doing the threes.

Another thing to consider is that galactose is often if not always missing in the sugar chains (glyproteins) of the tissues of the affected joints.

You can google for glyconutrients and RA might want to spell it out and see what you find.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11844062
Abnormal IgG galactosylation in MRL-lpr/lpr mice: pathogenic role in the development of arthritis.

Kuroda Y, Nakata M, Hirose S, Shirai T, Iwamoto M, Izui S, Kojima N, Mizuochi T.

Laboratory of Biomedical Research, Department of Applied Biochemistry, Tokai University, Hiratsuka, Japan.
MRL-lpr/lpr (MRL/lpr) mice spontaneously develop arthritis by an increase in the incidence of agalactosylated oligosaccharides in serum IgG, similar to rheumatoid arthritis patients. However, whether this association has a pathogenic significance is still unknown.

In this study, we analyzed the oligosaccharide structure of serum IgG in various MRL mice with or without arthritis, to clarify the relationship between the oligosaccharide abnormality and the development of arthritis.

The level of agalactosylation in serum IgG was comparable in both arthritis-free MRL/lpr and MRL-+/+ (MRL/+) mice at 6 weeks of age. In contrast, the incidence of IgG lacking galactose markedly increased in MRL/lpr mice at 6 months of age (the age at which arthritis occurred), compared with that from age-matched MRL/+ mice without arthritis. However, the proportion of agalactosylated IgG increased similarly in anti-CD4 monoclonal antibody-treated MRL/lpr mice at 6 months of age, despite the absence of the development of arthritis, because of depletion of CD4+ T cells.

These results suggest that the abnormality in IgG galactosylation of MRL/lpr mice developed in an age-dependent manner, but it did so independently of CD4+ T cell-dependent B-cell activation and is not a consequence of the development of arthritis.

PMID: 11844062

[MuseRider]

9. Good grief!

I was an RN and my husband was a doc and I don't know any of the things you are talking about. Right now I am really taking nothing specific for my RA. I am at the point where I have taken all the drugs available and am now left with Embrel or the other IV med if I need something. I refuse to take them. I was taking Imuran and it held it down pretty well. I had to stop it when I got pneumonia almost 2 years ago and I have stayed off of it since then. So far so good, flare ups are happening but I just get through them. My grandfather, his sister and an aunt on the other side all had this and they were so bad. I am very lucky that mine seems to be not too bad. My grandfather died because of complications from his meds so I am pretty leary of all of that but then you don't need to take cortizone for it like he had to. They were all in wheel chairs by the time they were my age. I am going to bookmark this and read it later when I get home, I have a party to go to. Thanks for the info. I have to admit, Immunology was my worst area but I will plug through it and see what I get from it. Thanks.

[HysteryDiagnosis]

11. There is a matrix that surrounds the cell walls in your body, do you want

to know what it is? He said in a Lawrence Fishburne sort of style...

Seriously though... I believe you can be totally free.

Getting back to the glycoproteins that form a matrix around your cells. They are made of proteins and saccharides (sugars)

These glycoproteins are responsible for all cellular messaging that takes place in the body.

There is a company that sells them in a 8 saccharide blend.

Read this, perhaps print it out and maybe have your rheumy cast his eyes upon it... he may understand what it is saying and if so you stand to benefit tremendously.

Parent site -----> www.Glycoscience.com

http://www.glycoscience.com/glycoscience/start_frames.wm?FILENAME=G002&MAIN=glyconutritionals&SUB=disease

[thethinker]

13. Question

4MoronicYears . . .

You seem quite knowledgeable about this stuff.

You said "Glad you are doing the fish oil thing however, remember, in an uncontrolled inflammatory state you want to adjust the ratio of your omega threes to your omega 6's."

You lost me with this.

What do you recommend a person buy and take? What brand name and how much would they take?

[HysteryDiagnosis]

14. What do you recommend a person buy and take?

Making any such recommendations would be tantamount to practicing medicine without a license. I am not fond of doing time in spite of the fact that you would probably achieve positive results with what I would say.

My suggestion is print out the paper from the Glycoscience site and take it to your doc.

Then you can read these books... but the ratio of omega three fats to omega fats in the last 100 years or so has gone from around 1 to 1 to around 50 to 2. (I don't know why they don't just say 25 to 1). It would be far better for all of us if it were 1 to 1 again. What happens when you have such an imbalance is prostaglandin production spins out of control when inflammation is present and the inflammatory state is able to feed off of itself. Balancing these fats has been shown to have a positive effect on this phenomenon.

http://www.amazon.com/exec/obidos/tg/detail/-/0684871394/qid=1104537459/sr=1-5/ref=sr_1_5/103-4660403-1359866?v=glance&s=books

The Omega-3 Connection: The Groundbreaking Antidepression Diet and Brain Program
by M.D., Andrew L. Stoll "During the course of reading this book you will learn about exciting research into a remarkable group of natural substances: the omega-3 fatty acids..." (more)
A must-read for anyone dealing with depression, The Omega-3 Connection by Andrew L. Stoll, M.D., strikes yet another blow against the standard American diet. We already know that years of noshing on highly processed foods have saddled us with sky-high rates of heart disease, obesity, and related conditions. But, as we're starting to understand now, our eating habits may also be subtly altering our brain chemistry, leaving us vulnerable to anxiety disorders and depression. Only in this case, it's not just what we're eating--it's what we're not eating: foods containing omega-3 essential fatty acids--the "good fats" that help maintain optimal brain function.

http://www.amazon.com/exec/obidos/tg/detail/-/9992239891/qid=1104537459/sr=1-1/ref=sr_1_1/103-4660403-1359866?v=glance&s=books

Omega-Three Fatty Acids and Heart Disease (Evaluation of Publicly Available Scientific Evidence Regarding Certain Nutrient Series)
by William E. Conner

http://www.amazon.com/exec/obidos/tg/detail/-/0060930233/qid=1104537459/sr=1-6/ref=sr_1_6/103-4660403-1359866?v=glance&s=books
The Omega Diet: The Lifesaving Nutritional Program Based on the Diet of the Island of Crete
by Artemis P. Simopoulos, Jo Robinson "IN RECENT YEARS, medical research has shattered many of our simplistic notions about diet..." (more)

[smirkymonkey]

4. I can personally vouch for this information...

I went off an SSRI over a month ago and was having terrible withdrawal and suicidal ideation UNTIL I had started taking Flax, Borage and Evening Primrose Oil REGULARLY. I feel 100% better, and I now have more energy from being off the medication.

[Stephanie]

5. how much do you take? n/t

[smirkymonkey]

15. Evening Primrose 1500 mg daily (3 capsules)

Flax and Borage 1800 mg daily - that is minimum, I take a little more around PMS time of the Evening Primrose.

[purduejake]

8. Isn't depression an epidemic?

Most of the people I know are taking some kind of antidepressant or something for anxiety. Most don't talk about it until you bring up the subject, though. I am going to tell everybody I know about this.

[HysteryDiagnosis]

12. I am going to tell everybody I know about this.

That was most perfect response I could have hoped for.

I have a coworker who admits he did poorly in school.. attentional problems.. hair trigger temper... the whole enchilada.

I started him on grape seed extract, fish oils, (Omega Threes/DHA), Calcium/Magnesium/Zinc blend, and B-Complex.

Recently his doc put him on something for sleep and depression.

He feels absolutely fantastic now... energy, mood, concentration etc.

He started his 50-something mother on the same regimen. She is banging out the aerobics every morning now, feels great too.... his thanks are very powerful indeed. I hope you receive some of the same sorts of thanks once you inform those who may need to know. Take care, be well.

[Richard D]

10. A couple points:

Quality is everything with fish oils. If it's not from good (non-farm raised) fish it may not have the same amount of the omega 3 fatty acids.

Make sure it's been purified. Otherwise it can contain PCB's and mercury.

Cod Liver oil is a good idea in the darker months since most of us are way deficient in Vitamin D.

Arctic Krill oil may be even better than salmon oil.

For some people, Flax or vegie oil won't work well. They may need fish oil to get the best effect.

[DARE to HOPE]

16. I am one of those--it needs to be fish...

an anchovie or sardine every several days really gives happiness and energy.

Also, look into using virgin coconut oil. The medium chain saturated fatty acids in VCO are anti-viral, anti-bacterial etc. good for the thyroid, and a great substitute for the corn and soy and yes, canola oils which give us all the omega-6. A little coconut oil actually BOOSTS the omega-3 availability from the fish oil. Also helps build the skin, bones, eyes, brain.

I made all our Christmas cookies with coconut oil and birch sugar (xylitol) this year--they were delicious during, and especially after, eating. :-)

[amazona]

17. caution--fish oil is a blood thinner

If you are on prescription blood thinners or have had a problem with bleeding due to aspirin or other reasons, check first with your doctor before taking fish oil.

Another caution to keep in mind that farm-raised (virtually 100 percent of all Atlantic salmon sold is farm-raised) does not contain Omega-3 because it is raised in warmer waters and does not consume the natural diet of the wild fish. If you are eating salmon, make sure it is Pacific wild salmon, or it is unlikely to have any of the Omega-3s in question. I will take it as a given that most people understand that eating an entire serving of fish gives much more of the nutrient than popping pills that only contain a relatively small amount of oil.

[Porcupine]

18. "Depression" masks environmental illness and...

several other chronic disease conditions that doctors are not interested in investigating. Newer buildings are frequently harboring mold and mildew colonies. Sometimes a tight or poorly ventilated building will also allow the buildup of toxic gasses from carpets, furnishings or cleaning products.

There are also a number of chronic disease conditions that present as depression such as lyme disease, fibromyalgia and others. Doctors attend regular seminars on Hawaii and the Bahama's where they are encouraged to veiw certain sets of symptoms as depression. There are no massive Pfizer sponsered education campaigns to make doctors aware of environmental toxins in the home or workplace.

In my personal case I was diagnosed with "depression" and given a series of drugs none of which worked. Even after I found out there was a mold bloom in my bedroom (I'm highly allergic to penicillin) no doctor would talk about connecting my symptoms with the mold. Only after the mold bloom had been cleaned up, my marriage had failed, I had been out of my house for months and I quit taking ALL prescription meds. did my health return.

Do NOT trust doctors. Investigate your living and working spaces carefully. Be vary wary of prescription medications and docs. who whip out the prescription pads.