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cancer, but also has a 3 fold greater risk than the average woman for developing it. She has "unordinary" cells in her breast tissue... but has opted out of the "preventive drug" route for now in lieu of regular monitoring..... interesting. Does she know? Was she told? Would she believe it? I3C with DIM is a supplement. Why doesn't this specialist know this? Why isn't she taking it? How much longer does the truth need to be ignored, buried, passed by?? As long as the pharmcos own the med schools methinks. Check out #16... both estrogen dependant and non-estrogen dependant cancers..... 1: Rahman KW, Sarkar FH. Related Articles, Links Abstract Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Cancer Res. 2005 Jan 1;65(1):364-71. PMID: 15665315
2: Chang X, Tou JC, Hong C, Kim HA, Riby JE, Firestone GL, Bjeldanes LF. Related Articles, Links Abstract 3,3'-diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis. 2005 Jan 20; PMID: 15661811
3: Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Related Articles, Links Abstract Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7. PMID: 15623462
4: Garcia HH, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL. Related Articles, Links Free Full Text Indole-3-carbinol (I3C) inhibits cyclin dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms and subcellular localization of the CDK2 protein complex. J Biol Chem. 2004 Dec 20; PMID: 15611077
5: Greenwald P. Related Articles, Links Abstract Clinical trials in cancer prevention: current results and perspectives for the future. J Nutr. 2004 Dec;134(12 Suppl):3507S-3512S. Review. PMID: 15570061
9: Rahman KM, Li Y, Sarkar FH. Related Articles, Links Abstract Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr Cancer. 2004;48(1):84-94. PMID: 15203382
13: Lee IJ, Han F, Baek J, Hisatsune A, Kim KC. Related Articles, Links Abstract Inhibition of MUC1 expression by indole-3-carbinol. Int J Cancer. 2004 May 10;109(6):810-6. PMID: 15027113
14: Chatterji U, Riby JE, Taniguchi T, Bjeldanes EL, Bjeldanes LF, Firestone GL. Related Articles, Links Abstract Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells. Carcinogenesis. 2004 Jul;25(7):1119-28. Epub 2004 Feb 26. PMID: 14988219
16: Brandi G, Paiardini M, Cervasi B, Fiorucci C, Filippone P, De Marco C, Zaffaroni N, Magnani M. Related Articles, Links Free Full Text A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines. Cancer Res. 2003 Jul 15;63(14):4028-36. PMID: 12874002
17: Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH. Related Articles, Links Free Full Text Indole-3-carbinol is a negative regulator of estrogen. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S. Review. PMID: 12840226
18: Firestone GL, Bjeldanes LF. Related Articles, Links Free Full Text Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr. 2003 Jul;133(7 Suppl):2448S-2455S. Review. PMID: 12840223
19: Sarkar FH, Rahman KM, Li Y. Related Articles, Links Free Full Text Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells. J Nutr. 2003 Jul;133(7 Suppl):2434S-2439S. Review. PMID: 12840220
20: Rahman KM, Aranha O, Sarkar FH. Related Articles, Links Abstract Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer. 2003;45(1):101-12. PMID: 12791510
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