LONDON (Reuters) - Far from making him better, the medication used to treat the madness of England's King George III may actually have made him worse, according to research published Friday.
One of the longest serving British monarchs who ruled for nearly 60 years, George had five very public bouts of madness culminating in his death -- blind, deaf and insane in January 1820.
The generally accepted theory has been that his fits of insanity -- the best documented lasting from October 1788 to February 1789 and triggering a constitutional crisis -- were due to a genetic disorder that caused variegate porphyria.
But there was no explanation of why the disease that causes symptoms such as lameness, hoarseness, acute abdominal pain, insomnia and temporary mental disturbances hit so late in his life or why the bouts were so deep and lasted so long.
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