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I've got a screwed up family, so all of that sounds normal. I could go into each case, but I won't. I'll just summarize. I was raised with two foster brothers, both of whom were very bad people as teenagers. Drugs, alcohol, sex, statutory rape, attempted murder (one of them)... Name it, they did it. One started straightening out about the time he turned eighten, then had a nervous breakdown and is still an invalid, basically. But he's a good guy. The other got worse, and by the time he ODed a couple of years ago, he had left behind a long list of victims of rape, theft, scams, and I would be surprised if there weren't a few murders in there.
That pattern repeated with other family members (won't go into detail) with some lost cases becoming good people, some turning out very, very bad, and some just being low-grade hustlers who do little harm to anyone not trying to hustle them back. Though one of them, not a relative, was just murdered in a drug deal gone bad.
My point is you can't tell what's going to happen. Teens don't always respond based on concepts of right and wrong, but rather on the concept of whether they feel wronged, and often they respond in measures appropriate to how wronged they feel (not how wronged they really were, if you see what I mean). So my uniformed point there is that your neice's poisoning of your sister may not have been, in her mind, an attempt to be really bad, so much as an attempt to right some wrong she feels your sis did to her (or that life did to her). Or, she could be a sociopath. Or, she could be too young to fully understand the consequences of her actions, only to see the immediate results that she wants. Best case is she outgrows that, worst case she doesn't.
That's just an insight into her, not advice on what to do. Don't let her get away with it, and if possible find a way to separate her influence from the younger sister. I would make two points: One, my parents tried very hard to show this derelict brother of mine that he was loved, that he fit in, that none of their actions against him were an attempt to harm him. He used all of that against us. He raped or tried to rape friends of mine because he felt increasingly invulnerable, as he realized more and more that my parents would do nothing of real consequence to him, aside from yelling, screaming, and grounding (a kid who doesn't obey rules against rape and robbery will not often pay much attention to being grounded). Because of this, I've had to admit, though I wouldn't tell my parents, I've come to see my parents as enablers who made the situation all worse while trying to do what was best for everyone. This brother was a true sociopath, so he would not have turned out good no matter what, but they made it easy for him to hurt people close to us.
So, my point is, don't let the big sister get away with it, and don't leave her in a situation where she can forcefully hurt people.
The second point is about me. I've never tried drugs for any reason, never been drunk, was always way too responsible sexually and emotionally, and am almost fanatical about following laws and not cheating on anything. A big part of that is because of what I saw my brothers doing, but part of it is also that my parents focused on making sure I didn't follow in their footsteps. Not by threats, but be talking to me. They told me what my brothers were doing, and let me see the harm they were causing. This made me want to be the opposite of them. So, concentrate on the younger sister, don't let all of your family energies go to the one lost child to the point of neglecting the younger one (and making her feel that the best way to get attention is to follow in sis's footsteps). Bring her in to the discussion, don't let her feel like an ousider, and don't get in the situation where she feels her crazy sister cares more for her (because she's telling her more of the gritty details) than her caring mother.
That's it, that's my short answer. Make sure the younger sister feels loved, accepted, and part of the group (making the bad sister the outsider), and don't, don't, DON'T become the enabler for the older sister (Obviously advice more for your sister than for you). There will be no easy solutions.
That's my advice, as little of it as I have. It might fit my family more than yours, in which case just ignore it. :) And good luck.
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