Remember when you are talking of West Virginia you are talking of an area with the least population per mile east of the Mississippi (i.e. the whole Appalachian Mountain Chain).
I live in the same mountain chain, wolves could survive in these mountain and did till the 1850 when rabies wiped them out of Pennsylvania. Pennsylvania has extensive State Forests and State Game Lands which along with forest owned by timber companies gives a nice size area for wolves to roam in. The biggest problem would be the various small farms in the area. Many already have extensive anti-deer fencing and anti-bear fencing (paid by the Game Commission) but with some additional fencing to keep the wolves out of certain areas it is a plan that could work. Pennsylvania and West Virginia already have a problem with Coyotes and the best way to get rid of Coyotes is the wolf. The wolf is bigger and goes after the same game, thus drives out the Coyotes. Coyotes evolved in the Great plains where there was NOT enough food to maintain a full-size wolf. Coyotes only spread from the Great Plains with the disappearance of the Wolf.
Thus in the Mountains of Pennsylvania and West Virginia Wolves are a viable thing to be introduced, the biggest concern will be the price. Remember when a new animal is introduced into an area any cost of introducing that animal must be incurred by the person or agency that introduced that animal. On the other hand if it comes in on its own that no one has to pay. The Pennsylvania Game Commission is willing to pay for Deer Fencing, and Bear Fencing, but it refuses to pay for damages done by Deer and/or Bears for the Game Commission did not Introduced either into Pennsylvania (The Game Commission doe SO some payments but that is to encouraged farmers harmed by the Deer and Bears not to shoot the Deer and Bears). The same with Wild Turkeys (Who cause very little damage). While Elk was native to Pennsylvania the Last Elk was killed in 1869 by a native American. Thus when the Game Commission re-introduced Elk in the 1930s it had to pay for any damage to the local farmers the Elk Caused. Due to financial concern of having to pay to much the Pennsylvania Elk head was kept Small from the 1930s till the 1980s when the Game Commission decided to risk the costs and leave the number of Elk to increase (and with that increase money the Game Commission had to pay out).
My point here is someone will have to pay for losses if the Wolf is reintroduced to the Appalachians (unless a couple of wolves migrant from Canada). In many regards you can see that the Game Commissions would like the wolf back into the State but prefers to wait and hope for some immigrants. West Virginia seems to have the same view, a good thing but can not afford to introduce wolves themselves. Wolves are in Quebec and Ontario and reported to be in the Adirondacks of New York State. If wolves are in the Adirondacks it is may take couple of decades but the Erie Canal and the New York Thruway is all that is between them and the rest of the Appalachians Mountains.
For the report of Wolves in the Adirondacks see:
http://www.gobacktothebasics.com/information_and_stories_on_the_adirondack_wolf.htmMore on Ginseng:
http://mdc.mo.gov/nathis/plantpage/flora/ginseng/Pa Game Commission:
http://www.pgc.state.pa.us/?dsftns=30149(Includes on line Topo Maps of Various State Game Lands)
Pa Bureau of State Forests (Includes State Forest's Maps):
http://www.dcnr.state.pa.us/forestry/State Forest are located in "Regions" thus you have to look at the actual topo map to see what areas in State Forest, State Parks and Game Commission lands (Game Commission maps do the same, i.e. indicate State Parks and State Forests in Addition to State Game Commission lands)
Pa State parks (Includes State Park Maps):
http://www.dcnr.state.pa.us/stateparks/index.aspxWest Virginia Department of Natural Resources:
http://www.wvdnr.gov/Here is a Typical Pa State Forest map. the State Forest is in light Green, State Parks is in darker gree, and the State Game land is in Brown. Other property is in white: