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The study shows that water fleas introduced to fertilizer chemicals in water were plagued with developmental and reproductive problems consistent with nitric oxide toxicity, even at what would be considered low concentrations.
This raises questions about the effect these chemicals may have on other organisms, says Dr. Gerald LeBlanc, professor of environmental and molecular toxicology at NC State and the corresponding author of the paper describing the results. He adds that additional research will be needed to explore those questions.
LeBlanc says that some of the study's results were surprising. "There's only limited evidence to suggest that animals could convert nitrates and nitrites to nitric oxide, although plants can," he says. "Since animals and plants don't have the same cellular machinery for this conversion, it appears animals use different machinery for this conversion to occur."
LeBlanc was also dismayed at seeing toxic effects at low chemical concentrations. "Nitrite concentrations in water vary across the United States, but commonly fall within 1 to 2 milligrams per liter of water," he says. "We saw negative effects to water fleas at approximately 0.3 milligrams per liter of water."
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http://www.sciencedaily.com/releases/2010/08/100827192023.htm