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I just got this article in an email. There was no link included. I tried to find this biomedical journal mentioned in the article but had no luck. So I don't know how reliable the source is but I found the info interesting.
Gene scan suggests homosexuality origin
by David Ryan Alexander PlanetOut Network
A new genetic study released Jan. 12 claims to "help explain why some men are gay and other men are heterosexual." The study, published in the biomedical journal Human Genetics, analyzed 456 individuals from 146 unrelated families with two or more gay brothers and claims to be the first full genome scan of sexual orientation in men.
"We found three chromosomal regions that are likely to have genes within them that influence sexual orientation," said Brian Mustanski of the University of Illinois, one of the six scientists from a number of institutions who conducted the study.
"I think we essentially found these regions that are likely to influence sexual orientation," Mustanski said. "We found some genes that influence hormones and brain development. The next step is to look at specific genes in a new family sample to see if those are the exact genes that affect sexual orientation."
The study also stated that "given the complexity of sexual orientation, numerous genes are likely to be involved, many of which are expected to be autosomal (or of a non-sex chromosome) than sex- linked." In previous studies regarding gay male twins, the report said, only limited connection could be made showing male sexual orientation as being inherited from the X-chromosome, or sex chromosome.
"Previous research had looked exclusively at the X-chromosome," Mustanski said, "and found that the region right at the tip of the X- chromosome may influence sexual orientation."
The current study sought to provide a scan analyzing both sex and non-sex chromosomes to identify all genes that potentially contribute to variation in sexual orientation.
Mustanski compared the study to finding one person in a town of 40,000 people. "You make some assumptions about where they might be, knocking on one door on every street," he said. "You're going to narrow it down considerably."
According to Mustanski another study exploring the genetics of sexual orientation is currently being conducted, and he assumed its researchers would incorporate these new findings into their study, but it will still probably be years until that report is completed.
As for exactly what locating these genes would mean, Mustanski said, "Finding the specific genes would have implications beyond uncovering the cause of homosexuality. Their identification would also greatly advance our understanding of human variation, evolution and brain development."
Mustanski also placed importance on studies focusing on women. "As with many things," he said, "females tend to be studied last and it would be important to start looking at female sexuality."
Posted January 21, 2005
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