BERLIN—Patients suffering from the agony of cluster headaches will take anything to dull the pain, even LSD, it turns out. Results from a pilot study presented here on Saturday at the International Headache Congress reveal that six patients treated with 2-bromo-LSD, a nonhallucinogenic analog of LSD, showed a significant reduction in cluster headaches per day; some were free of the attacks for weeks or months.
"Some of these patients are still reporting significant relief more than a year after they were treated with the compound," says John Halpern, a psychiatrist at Harvard Medical School in Boston and one of the investigators involved in the study. "Nobody has ever reported these kinds of results."
Cluster headaches, sometimes referred to as "suicide headaches" because of the almost unbearable pain they cause sufferers, usually involve just one side of the face; patients often liken the pain to someone trying to pull their eye out for hours. They can occur in bouts lasting many weeks, with several attacks a day.
"What causes these attacks is still not clear," says Peter Goadsby, a headache expert at the University of California, San Francisco, who is not connected with the research. But recent studies suggest that changes in the structure of the hypothalamus are involved. Because that part of the brain is responsible for, among other things, circadian rhythms, the daily cycle of our body that dictates when we sleep but also regulates body temperature and blood pressure, it could explain the periodicity of attacks and why they seem to occur particularly often around the solstices.
http://news.sciencemag.org/sciencenow/2011/06/lsd-alleviates-suicide-headaches.html?ref=hp