$8000/month breast cancer drug Avastin neither efficient nor safe

[ellenrr]

An FDA panel of experts has confirmed earlier findings that Avastin is neither efficient nor safe.

The Oncologic Drugs Advisory Committee was convened at the drugmaker's request to appeal the FDA's earlier decision to remove bevacizumab's indication to treat locally recurrent or metastatic HER2-negative breast cancer.

The committee endorsed that decision after voting unanimously that the drug does not work and is not safe.

http://www.medpagetoday.com/PublicHealthPolicy/FDAGeneral/27357

FDA approved Avastin for treating breast cancer patients in 2008, based only on a single study carried out by the producing company, which suggested that the drug could improve lifespan of patients with metastatic breast cancer for 5.5 years in average.

However, further subsequent investigations failed to support those findings and showed that the drug may cause serious adverse effects such as high blood pressure, heart attacks and bleeding.

http://www.presstv.ir/detail/186869.html

[HysteryDiagnosis]

1. Sloan Kettering on I3C about $20 a month.

http://www.mskcc.org/mskcc/html/69263.cfm

Clinical Summary
Indole-3-Carbinol (I3C) is a specific compound found in cruciferous vegetables including broccoli, cabbage and cauliflower. Because diets high in these vegetables retard cancer growth in animals, I3C is thought to be a good candidate for cancer prevention (1). Data from clinical trials show that I3C is effective in treatment of precancerous cervical dysplasia (2) and vulvar intraepithelial neoplasia (3). In premenopausal women, a supplement containing I3C and 7-hydroxymatairesinol significantly increased the urinary 2:16-hydroxyestrone ratio, a known biomarker for the reduction of breast cancer risk (4). I3C also stimulates detoxification enzymes in the gut and liver (5). Several in vitro studies demonstrate that it can cause cell cycle arrest (6) (7) and apoptosis (8) (9) (10) (11) (12) in cancer cell lines. I3C is generally well tolerated when taken orally. I3C may promote tumor growth in animals that have been exposed to carcinogens (13). Because it may induce cytochrome P450 enzymes (14), I3C may interact with several medications.
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Food Sources
Broccoli, brussel sprouts, cabbage, cauliflower, collards, kale, kohlrabi, mustard greens, rapeseed, rutabaga, turnip

[Mugweed]

2. Since when has efficient and safe been important to big pharma?

You just pay for FDA approval, get your drug on the market with multiple "ask your doctor about..." ads, and make as much money as possible until the death toll mounts to the point that it has to be pulled. That's western medicine in one sentence.

[Sarah Ibarruri]

3. And this isn't the first time it's been found ineffective and dangerous nt

[izquierdista]

4. bevacizumab?

Who thinks up these names? I'll bet it means "little red shitwagon" in Lithuanian or some other obscure language.

[bemildred]

5. Now there is some "Woo science" for you. nt