Mainstream medicine backs up what the "supplement companies" have been knowing

[HysteryDiagnosis]

for years.

http://www.ncbi.nlm.nih.gov/pubmed/21906026

Recent Pat Cardiovasc Drug Discov. 2011 Sep 1;6(3):222-41.
Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases.
Aliev G, Li Y, Palacios HH, Obrenovich ME.
Source

School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, Georgia, USA. [e-mail].
Abstract

Oxidative stress in the cardiovascular system, including brain microvessels and/or parenchymal cells results in an accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) compounds thus promoting leukocyte adhesion and increasing endothelial permeability. The resulting chronic injury stimulus results in progressive cellular hypometabolism. We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells.

At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. Vascular endothelial and neuronal mitochondria are especially vulnerable to oxidative stress due to their role in energy supply and use, which can cause a cascade of debilitating factors such as the production of giant and/or vulnerable young mitochondrion who's DNA has been compromised.

Therefore, mitochondrial DNA abnormalities such as overproliferation and or deletion can be used as a key marker for diseases differentiation and effectiveness of the treatment. We speculate that specific antioxidants such as acetyl-L-carnitine and R-alpha lipoic acid seem to be potential treatments for AD.

They target the factors that damage mitochondria and reverse its effect, thus eliminating the imbalance seen in energy production and restore the normal cellular function, making these antioxidants very powerful alternate strategies for the treatment of cardiovascular cerebrovascular as well as neurodegenerative diseases including AD. Future potential exploration using mtDNA markers can be considered more accurate hallmarks for diagnosis and monitoring treatment of human diseases. The present article discusses some of the patents regarding the oxidative stress.

PMID:
21906026

[KT2000]

1. Yes - they are catching up.

Martin Pall, PhD has been linking conditions such as CFS, MCS, GWS, Fibromyalgia, Alzheimer's etc. to the Nitric oxide cycle. In these conditions he proposes that the cycle, which is triggered by an insult such as toxic chemical exposure, physical injury or psychological stress, does not turn off. The nitric oxide cycle is supposed to be a short lived event. In people with these and other illnesses, it is stuck in the ON position thereby creating additional oxidative stress and damage.

www.thetenthparadigm.org

[HysteryDiagnosis]

3. They are catching up and when it if found that many of the pharmaceutical drugs

being hawked today as the best thing since sliced bread are revealed as unnecessary since there are safer and saner methods available they will try to outlaw them. They will have little choice.

[arendt]

2. I take both, and some other "natural" stuff...

If you check it out, the statistic is that something like 80% of all pharmaceutical drugs are either natural products or designed mimics or derivatives of natural products.

Its great to see this in the medical literature.

BTW, if you go to that site, you can ask to "see all" of the related articles. The relation DB does a pretty good job of finding relevant related articles. Some of them are open access; or you can sign up for Science Direct.

[HysteryDiagnosis]

4. Yes they are bastardized versions which makes them patentable, not necessarily safe,

not necessarily better, just in many cases expensive in the extreme.