By R. Douglas Fields | October 19, 2011
ROCKVILLE, Md.—A new experiment aimed at achieving actor Christopher Reeve's dream of finding an effective treatment for spinal paralysis was announced this week at an international meeting of scientists and people with spinal cord injury sponsored by the United 2 Fight Paralysis Foundation. The approach, which already is shown to be promising in animals and avoids the need for patients to take immunosuppressive drugs, has not yet been proved effective in humans. Nonetheless, patients are excited to see this advance as they have been frustrated waiting for the first human trials of the new approach.
W. Dalton Dietrich, scientific director of The Miami Project to Cure Paralysis at the University of Miami Miller School of Medicine, announced here that his research team has submitted an application to the U.S. Food and Drug Administration (FDA) for permission to begin new "phase I" experiments on humans to treat paralysis using the new cell transplantation technique. (Phase I trials have nothing to do with efficacy. They are only to test safety and typically a nontherapeutic dose is used at the outset of the safety studies.) With the new technique, rather than using cells derived from embryonic stem cells, the patient's own mature cells are harvested from a nerve in the leg and grown in large numbers in the laboratory, then transplanted back into the injured spinal cord to repair damage. This approach avoids the problems of immunological rejection and the controversy that can arise from using cells derived from embryonic stem cells for treating neurological injury and disease. Typically, patients receiving an organ or tissue transplant from a donor must be given immunosupressant drugs to prevent their immune systems from attacking the foreign tissue.
The cells being used for transplantation are Schwann cells, a type of non-neuronal cell (glia) that protects and insulates nerve fibers running through the body's limbs and trunk. Schwann cells also support the repair of damaged neurons; they provide vital proteins that protect nerve cells after injury, coax new nerve sprouts (axons) to grow and reconnect with the proper structures, and wrap electrical insulation, myelin, around the fibers, which is essential for axons to conduct electrical impulses. Unlike damage to the spinal cord, an injured nerve in the body can repair itself.
Schwann cells are not present in the brain and spinal cord. Instead, a different cell called an oligodendrocyte forms the myelin insulation. This century-old observation was an important clue in answering the question of why a damaged nerve in the body's peripheral nervous system heals over time, but a damaged axon in the brain or spinal cord (central nervous system, or CNS) does not. Research transplanting Schwann cells into the damaged brain and spinal cord of experimental animals in the 1980s showed that neurons in the CNS could grow and repair damaged connections if Schwann cells were transplanted to support and guide them. This finding has been replicated in numerous studies in a wide range of animals. The cellular environment in the central nervous system is the reason that spinal cord injury results in permanent paralysis, not a weakness of the neurons themselves in recovering from damage.
more
http://www.scientificamerican.com/article.cfm?id=preliminary-human-experiments-test-safety-paralysis-treatment-nerve-cells
Printer-friendly format
Email this thread to a friend
Bookmark this thread
(1000+ posts)
Send PM |
Profile |
Ignore
