First one thing: IBTL
This is a medical hypothesis. They hypothesize potential reasons for the development of acne. What you make of it is your business. That is all.
http://www.ncbi.nlm.nih.gov/pubmed/17448607Med Hypotheses. 2007;69(5):1080-4. Epub 2007 Apr 19.
Acne vulgaris: nutritional factors may be influencing psychological sequelae.
Katzman M, Logan AC.
Source
START Clinic for Mood and Anxiety Disorders, University of Toronto, 790 Bay St., Toronto, Canada ON M5G 1N8. mkatzman@startclinic.ca
Abstract
Acne vulgaris is a distressing skin condition which can carry with it significant psychological disability. Patients with acne are more likely to experience anger and are at increased risk of depression, anxiety, suicidal ideation. Certain nutrients which have been implicated as influencing the pathophysiology of acne have also been identified as important mediators of human cognition, behavior and emotions. Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety. These same nutrients, along with systemic oxidative stress and an altered intestinal microflora have been implicated in acne vulgaris. It is our contention that certain nutritional factors, a weakened antioxidant defense system and altered intestinal microflora may interplay to increase the risk of psychological sequelae in acne vulgaris.
PMID:
17448607
http://www.ncbi.nlm.nih.gov/pubmed/21143923
Lipids Health Dis. 2010 Dec 9;9:141.
Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles.
Bowe WP, Logan AC.
Source
Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA. wpbowe@gmail.com
Abstract
Acne vulgaris is a common dermatological disorder, one that is frequently associated with depression, anxiety and other psychological sequelae. In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. Emerging studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress. Indeed, there are indications that lipid peroxidation itself is a match that lights an inflammatory cascade in acne.
The notion that lipid peroxidation is a 'starter gun' in acne is not a new one; here we review the nearly 50-year-old lipid peroxidation theory and provide a historical perspective to the contemporary investigations and clinical implications.In addition, we present a novel hypothesis in which lipid peroxidation may be priming an increased susceptibility to co-morbid depression and anxiety in those with acne. The emerging research on the systemic burden of oxidative stress in acne sheds further light on the brain-skin axis. The recent findings also suggest potential avenues of approach for the treatment of acne via specific nutrients, dietary modifications, oral and topical interventions.
PMID:
21143923
PMCID: PMC3012032
Free PMC Article