Intestinal Dysbiosis and Mental Health

[HysteryDiagnosis]

http://integrativemedicineformentalhealth.com/articles/shaw_hphpa.html

Usefulness of HPHPA marker in a wide range of neurological, gastrointestinal, and psychiatric disorders by William Shaw, Ph.D.

The dysbiosis marker 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), the predominant dihydroxyphenylpropionic acid isomer in urine, is also measured in the Organic Acids Test offered by The Great Plains Laboratory. This marker was proven by Dr. William Shaw to be due to a combination of human metabolism and the metabolism by a group of Clostridia species, including but not limited to C. difficile.

HPHPA has been one of the most useful clinical markers in recent medical history. Treatment with metronidazole, vancomycin, or high doses of probiotics of individuals with high urinary values has led to significant clinical improvements or remissions of psychosis.

The biochemical role of Clostridia in altering brain neurotransmitters is due to the fact that Clostridia metabolites inactivate dopamine beta-hydroxylase, leading to an excess production of brain dopamine and reduced levels of the neurotransmitter norepinephrine. Excess dopamine is associated with abnormal or psychotic behavior. This imbalance can be demonstrated in the Organic Acids Urine Test by observing the ratio of the major dopamine metabolite, homovanillic acid (HVA), to that of the major norepinephrine metabolite, vanillylmandelic acid (VMA) when the Clostridia marker HPHPA is elevated. After treatment with metronidazole or vancomycin, HPHPA values return to normal along with normal ratios of HVA/VMA and normal behavior.

The highest value of HPHPA was measured in the urine of a young woman with first onset of schizophrenia. Treatment of Clostridia bacteria resulted in loss of auditory hallucinations. In autism, children with gastrointestinal Clostridia commonly exhibit aggressive behavior, agitation, obsessive compulsive behavior, and irritability. They may have very foul stools with diarrhea with mucus in the stools although some individuals may be constipated. Stool testing for Clostridia is usually of limited usefulness since most Clostridia species are considered probiotics or beneficial. There are about 100 species of Clostridia that are commonly found in the gastrointestinal tract. Only seven of these species are producers of HPHPA including C. sporogenes, C.botulinum, C. caloritolerans, C. angenoti, C. ghoni, C.bifermentans, C. difficile, and C. sordellii while C. tetani,C. sticklandii, C. lituseburense, C. subterminale, C.putifaciens, C. propionicum, C. malenomenatum, C.limosum, C. lentoputrescens, C. tetanomorphum, C.coclearium, C. histolyticum, C. aminovalericum, and C.sporospheroides do not produce compounds that are converted to HPHPA.

[MineralMan]

1. I'm curious. What is it that you think this means?

[HysteryDiagnosis]

2. It may mean that there is more to being crazy than just being so. It may

mean that orthomolecular medicine has its place and that getting to the root of the problem should be medicines one and only goal.

[MineralMan]

3. That does not answer my question in any way.

So, you posted this. You must have been trying to inform people about something. So, can you tell us what that was, in lay terms? If not, what is the point of posting the article. The thing is that I know what it says, because I'm used to reading such thing. Apparently, however, you do not know what it says, since you answered my question with obfuscation.

You can try again, though...

[HysteryDiagnosis]

4. Read it again.

The highest value of HPHPA was measured in the urine of a young woman with first onset of schizophrenia. Treatment of Clostridia bacteria resulted in loss of auditory hallucinations. In autism, children with gastrointestinal Clostridia commonly exhibit aggressive behavior, agitation, obsessive compulsive behavior, and irritability. They may have very foul stools with diarrhea with mucus in the stools although some individuals may be constipated. Stool testing for Clostridia is usually of limited usefulness since most Clostridia species are considered probiotics or beneficial.

[uppityperson]

5. May have diarrhea or constipation? Autistic kids may be agitated, OC, irritable?

huh

[HysteryDiagnosis]

6. Why don't you just go here and have a chuckle... cuz that is what

will probably happen. www.hriptc.org

[HuckleB]

7. What is the point in pushing this place on people again?

As already noted:

It utilizes the usual self-selected preliminary "studies" in order to sell unproven therapies. Interestingly, the name A. Wakefield is attached to some of those "studies."

http://www.hriptc.org/content/researchHome.php

Goodness, gracious.

[uppityperson]

8. I do find it amusing that diarrhea and constipation may be associated. And the associated symptoms

of autistic kids, symptoms that relate to their autism. Thanks for the chuckle advice, I already have.