Multiple sclerosis reversed with stem cell therapy

[sfpcjock]

Multiple sclerosis 'reversed' with stem cell therapy

New Scientist, 30 January 2009 by Linda Geddes

For the first time, some of the disability associated with the early stages of multiple sclerosis appears to have been reversed. The treatment works by resetting patients' immune systems using their own stem cells.

While randomised clinical trials are still needed to confirm the findings, they offer new hope to people in the early stages of the disease who don't respond to drug treatment.

Multiple sclerosis is an autoimmune disease in which the fatty myelin sheath that wraps around nerve cells and speeds up their rate of transmission comes under attack from the body's own defences.

Clean slate

Richard Burt of Northwestern University Feinberg School of Medicine in Chicago and his colleagues had previously tried using stem cells to reverse this process in patients with advanced stages of the disease, with little success.

"If you wait until there's neuro-degeneration, you're trying to close the barn door after the horse has already escaped," says Burt. What you really want to do is stop the autoimmune attack before it causes nerve-cell damage, he adds.

In the latest trial, his team recruited 12 women and 11 men in the early relapsing-remitting stage of MS, who had not responded to treatment with the drug, interferon beta, after six months.

They removed stem cells from the patients' bone marrow, and then used chemicals to destroy all existing immune cells in the body, before re-injecting the stem cells. These then developed into naïve immune cells that do not see myelin as alien, and hence do not attack it.

Three years later, 17 of the patients had improved by at least one point on a standard disability scale, while none of the patients had deteriorated.

First reversal
"For the first time ever in the history of treating MS we have reversed disability," says Burt.

He cautions that more trials are needed to confirm the findings – and these are now underway – but eventually, stem cell transplantation could provide an alternative to drugs in patients who don't respond to them. Transplantation also has the benefit of being a one-off treatment.

"These are very encouraging results, and it's exciting to see that in this trial not only is progression of disability halted, but damage appears to be reversed," says Doug Brown at the UK's MS Society.

"Stem cells are showing more and more potential in the treatment of MS and the challenge we now face is proving their effectiveness in trials involving large numbers of people," he says.

Journal reference: The Lancet Neurology (DOI: 10.1016/S1474-4422(09)70017-1)

[Sylvarose]

1. thank you for posting this

My mom had MS page..and eventually died from resulting problems created by the disease. I now have another young member of my family who has been diagnosed with it.

sr

[mitchtv]

2. I hope they make progress with Parkinson's too

I'm starting to show symptoms

[WePurrsevere]

3. Very cool... I have relapsing-remitting MS so this gives me a lot of hope...

for others this tech might help as well as myself... although it may not be soon enough to really help me. Time will tell. :)

[Patiod]

4. Keep in mind New Scientist reports EARLY research

It's an amazing publication, and they are pretty good about including caveats:
"He cautions that more trials are needed to confirm the findings – and these are now underway"
but keep in mind they focus on the new, the cutting edge and to some extent, the speculative (but at least they're careful to label speculation as speculation rather than fact).

This is good news, but we need to see if it holds up in more extensive research. Folks with MS have gotten their hopes raised so often.