Is vitamin C an antiinflammatory agent?
The March, 2006 issue of
The American Journal of Clinical Nutrition published the findings of UK researchers of an association between dietary and plasma levels of vitamin C and reduced markers of inflammation and endothelial dysfunction in older men.
It was found that higher plasma vitamin C levels, greater fruit intake, and greater vitamin C intake were all correlated with lower levels of C-reactive protein and t-PA. High vegetable intake was associated with a reduction in t-PA but not C-reactive protein. Men whose plasma vitamin C was in the highest one-fourth of participants had a 44 percent less risk of having elevated C-reactive protein and a 21 percent lower risk of an elevated t-PA than those whose levels were in the lowest fourth. For those whose fruit intake was in the top quarter the risk of having either factor elevated was 24 percent lower than that of men whose fruit intake was in the bottom fourth. Additionally, higher plasma vitamin C levels were associated with reduced blood viscosity and fibrinogen concentrations.
“Several studies have reported that vitamin C can improve endothelial dysfunction in smokers, hypertension patients, and patients with coronary artery disease,” the authors write.
“Our finding is consistent with a protective effect of vitamin C on endothelial function, which could be mediated by the effects of vitamin C on low-grade inflammation, effects that may result from its antioxidant properties". http://www.lef.org/Lefcms/Template/NewsletterArchive.aspx?NRMODE=Published&NRORIGINALURL=%2fnewsletter%2f2006%2f2006_03_11%2ehtm%3fsource%3deNewsLetter2006Wk10-2%26key%3darchive&NRNODEGUID=%7b2F6EB6CB-C17B-4F9F-A8C4-0AE17FB4CA7E%7d&NRCACHEHINT=Guest&key=archive&source=eNewsLetter2006Wk10-2#exc The American Journal of Clinical Nutrition Study - Full Text:
http://www.ajcn.org/cgi/content/full/83/3/525