http://psa-rising.com/foodnews/2009/10/sulforaphane-hdac-inhibitor/Broccoli compound may aid survival for high-risk prostate cancer patients
31 October 2009 Filed under Broccoli, Cancer, Colorectal, Bowel, Phytochemicals, Prostate Cancer Posted by admin » No Comments
Scientists at Oregon State University and Linus Pauling Institute propose in an article published October 7 that sulforaphane, a compound found in cruciferous vegetables notably broccoli, may be useful as a chemopreventive agent for high-risk prostate cancer patients. Sulforaphane, Emily Ho and colleagues write, acts as a histone deacetylase inhibitor on prostate cancer (and colorectal cancer) cells.
Levels of sulforaphane in cruciferous vegetables including broccoli are low, of course, compared to levels of HDAC inhibitors tested in laboratory studies on cancer cells, in mice and (see below) on patients in clinical trials. Nonetheless, the authors of the current study write: