New Compound Safely Reduces Plaques in Mouse Model of Alzheimer's Disease

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http://www.sciencedaily.com/releases/2010/09/100908121917.htm


New Compound Safely Reduces Plaques in Mouse Model of Alzheimer's Disease
ScienceDaily (Sep. 9, 2010) — A team of scientists, led by University of California, San Diego School of Medicine researchers, has synthesized hundreds of new compounds with the potential of reducing the production of the A-beta 42 peptide, a primary component of Alzheimer's disease (AD).

In mouse models, one tested compound specifically reduced levels of A-beta 42, which is believed to be responsible for the destruction of neurons, but left other essential enzymatic activities in the brain unaffected, said Steven Wagner, PhD, a project scientist in the UCSD Department of Neurosciences.
The research, which will be published in the September 8 advance online edition of the journal Neuron, includes collaborators at the University of Chicago, Memorial Sloan Kettering Cancer Center, Massachusetts General Hospital and several San Diego-based biotechnology companies.