Liver Defect Likely Cause of DHA Deficiency in Alzheimer's Patients

[HysteryDiagnosis]

http://www.sciencedaily.com/releases/2010/09/100908171122.htm


Liver Defect Likely Cause of DHA Deficiency in Alzheimer's Patients, UCI Study Finds
ScienceDaily (Sep. 8, 2010) — UC Irvine researchers have discovered that markedly depleted amounts of an omega-3 fatty acid in brain tissue samples from Alzheimer's patients may be due to the liver's inability to produce the complex fat, also contained in fish-oil supplements.

Low levels of docosahexaenoic acid, or DHA, have been associated with the chronic neurodegenerative disease affecting millions of Americans, but no cause had been identified.
In postmortem liver tissue from Alzheimer's patients, the UCI team found a defect in the organ's ability to make DHA from shorter molecules present in leafy plants and other foods. Previous studies have shown that most brain DHA is manufactured in the liver.

Non-Alzheimer's livers did not have this defect, said Daniele Piomelli, the Louise Turner Arnold Chair in the Neurosciences and director of the Center for Drug Discovery at UCI, who led the research with Giuseppe Astarita, project scientist in pharmacology.

[Extend a Hand]

1. closer and closer

I sure do hope they can find a cure or at least and effective treatment...It's a cruel disease.

[HysteryDiagnosis]

3. 12 years ago I was saying that there was something going on with

ADHD, Autism, Alzheimer's and essential fatty acid availability in the body. Turns out I was right.

EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
Gustafsson PA, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H, Strandvik B, Karlsson T.

.Department of Child Psychiatry, Linköping University, Linköping, Sweden.
Abstract
Abstract Aim: Measure efficacy of eicosapentaenoic acid (EPA) in children with attention deficit hyperactivity disorder (ADHD). Methods: Randomized controlled trial (RCT) of 0.5 g EPA or placebo (15 weeks) in 92 children (7-12 years) with ADHD. Efficacy measure was Conners' Parent/Teacher Rating Scales (CPRS/CTRS). Fatty acids were analysed in serum phospholipids and red blood cell membranes (RBC) at baseline and endpoint with gas chromatography. Results: EPA improved CTRS inattention/cognitive subscale (p = 0.04), but not Conners' total score. In oppositional children (n = 48), CTRS total score improved >/=25% in 48% of the children receiving EPA vs. 9% for placebo . In less hyperactive/impulsive children (n = 44), >/=25% improvement was seen in 36% vs. 18% (ES 0.41, n.s.), and with both these types of symptoms 8/13 with EPA vs. 1/9 for placebo improved >/=25% (p = 0.03). Children responding to treatment had lower EPA concentrations (p = 0.02), higher AA/EPA (p = 0.005) and higher AA/DHA ratios (p = 0.03) in serum at baseline. Similarly, AA/EPA (p = 0.01), AA/DHA (p = 0.038) and total omega-6/omega-3 ratios (p = 0.028) were higher in RBC, probably because of higher AA (p = 0.011). Conclusion: Two ADHD subgroups (oppositional and less hyperactive/impulsive children) improved after 15-week EPA treatment. Increasing EPA and decreasing omega-6 fatty acid concentrations in phospholipids were related to clinical improvement.

[trotsky]

4. Oh please.

You push any and every supplement, and in traditional fashion, ignore your 99 misses and celebrate the 1 thing that almost looks like a hit.

[HuckleB]

5. Well, pushing fiction about oneself is an Internet bonus!

[HysteryDiagnosis]

6. ... large amounts of vacuum there sport. Do the math.

Health benefits of docosahexaenoic acid (DHA)
Horrocks LA, Yeo YK.

Docosa Foods Ltd, 1275 Kinnear Road, Columbus, OH 43212-1155, USA,
Comment in:

Pharmacol Res. 1999 Sep;40(3):203.
Pharmacol Res. 1999 Sep;40(3):205-6.
Abstract
Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability, whereas deficiencies of DHA are associated with deficits in learning. DHA is taken up by the brain in preference to other fatty acids. The turnover of DHA in the brain is very fast, more so than is generally realized. The visual acuity of healthy, full-term, formula-fed infants is increased when their formula includes DHA.

During the last 50 years, many infants have been fed formula diets lacking DHA and other omega-3 fatty acids. DHA deficiencies are associated with foetal alcohol syndrome, attention deficit hyperactivity disorder, cystic fibrosis, phenylketonuria, unipolar depression, aggressive hostility, and adrenoleukodystrophy. Decreases in DHA in the brain are associated with cognitive decline during aging and with onset of sporadic Alzheimer disease. The leading cause of death in western nations is cardiovascular disease. Epidemiological studies have shown a strong correlation between fish consumption and reduction in sudden death from myocardial infarction.

The reduction is approximately 50% with 200 mg day(-1)of DHA from fish. DHA is the active component in fish. Not only does fish oil reduce triglycerides in the blood and decrease thrombosis, but it also prevents cardiac arrhythmias. The association of DHA deficiency with depression is the reason for the robust positive correlation between depression and myocardial infarction. Patients with cardiovascular disease or Type II diabetes are often advised to adopt a low-fat diet with a high proportion of carbohydrate.

A study with women shows that this type of diet increases plasma triglycerides and the severity of Type II diabetes and coronary heart disease. DHA is present in fatty fish (salmon, tuna, mackerel) and mother's milk. DHA is present at low levels in meat and eggs, but is not usually present in infant formulas.

EPA, another long-chain n-3 fatty acid, is also present in fatty fish. The shorter chain n-3 fatty acid, alpha-linolenic acid, is not converted very well to DHA in man. These longchain n-3 fatty acids (also known as omega-3 fatty acids) are now becoming available in some foods, especially infant formula and eggs in Europe and Japan. Fish oil decreases the proliferation of tumour cells, whereas arachidonic acid, a longchain n-6 fatty acid, increases their proliferation. These opposite effects are also seen with inflammation, particularly with rheumatoid arthritis, and with asthma. DHA has a positive effect on diseases such as hypertension, arthritis, atherosclerosis, depression, adult-onset diabetes mellitus, myocardial infarction, thrombosis, and some cancers.

PMID: 10479465

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[HuckleB]

7. Thanks for more of the usual.

:rofl:

[HysteryDiagnosis]

8. Now run upstairs and go to bed. n/t

[HuckleB]

9. Awwwwwwwwwwwwwwwww.

I'm sorry to burst your fantasy bubble.

:rofl:

[HysteryDiagnosis]

10. A truly bad case of the imaginaries but it can be cured, check into

DHA, try here, www.DHADepot.com see if they can help you.

[HuckleB]

11. Oh, goodness.

:rofl:

[JanusAscending]

2. Amazing things are happening in this research !!

It's sadly too late for my Mom who suffered with it for 11 long years, and so many others. I donated my Mom's brain to the research for this when she passed 9 years ago as she would have wanted. Each new discovery brings us closer to a definite cause and perhaps a cure. I pray that this is no longer the scourge that it is when my grand children are old enough to worry about it!