Opening new frontiers: First volume of microbial encyclopedia published

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Published: Wednesday, December 23, 2009 - 14:27 in Biology & Nature

The Earth is estimated to have about a nonillion (1,000,000,000,000,000,000,000,000,000,000) microbes in, on, around, and under it, comprised of an unknown but very large number of distinct species. Despite the widespread availability of microbial genome data—close to 2,000 microbes have been and are being decoded to date—a vast unknown realm awaits scientists intent on exploring microorganisms that inhabit this "undiscovered country." Two thousand years after Pliny the Elder compiled one of the earliest surviving encyclopedic works, and in the spirit of his goal of providing "light to the obscure," the Department of Energy Joint Genome Institute (DOE JGI) has published the initial "volume" of the Genomic Encyclopedia of Bacteria and Archaea (GEBA). Presenting a provocative glimpse into this uncharted territory, an analysis of the first 56 genomes representing two of the three domains of the tree of life appears in the December 24 edition of the journal Nature.

"Microbes mediate almost every conceivable biological process on the planet and genome sequencing has revolutionized our understanding of the diverse roles that they play," said DOE JGI Director Eddy Rubin. "The information from this first set of organisms has provided a rich source of novel enzymes and detailed biochemical pathways that can help scientists optimize processes of critical importance to areas of the DOE mission, such as biofuels production, bioremediation, and how carbon is captured and cycled in the environment."

Most studies in microbiology have exploited a narrow subset of the evolutionary diversity of bacteria and archaea known to exist, and were selected more for convenience (and because they cause diseases) rather than the opportunity to advance discovery science. From the tree of microbial diversity the genomes from only a few branches have been sequenced. The DOE JGI is now exploring Earth's microbial "dark matter" with a project to sequence little-studied microbial species that will inform other microbes and complex microbial communities.

more:
http://esciencenews.com/articles/2009/12/23/opening.new.frontiers.first.volume.microbial.encyclopedia.published