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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Jan-07-09 02:15 PM
Original message
Penytoin (Dilantin) and inability to walk
Edited on Wed Jan-07-09 02:23 PM by bonito
Still is not recognized here in the US it's a toxic effect unrecognizable for lack of information provided to health care professionals here but is provided internationally here http://www.inchem.org/documents/pims/pharm/pim416.htm

2.2 Summary of clinical effects

Onset of symptoms including lateral nystagmus, ataxia,
and drowsiness occurs within 1 to 2 hours after ingestion and
may persist for about 4 to 5 days.
In more severe cases, horizontal nystagmus, coarse tremor and
inability to walk may be observed.
In very severe poisoning, conciousness is impaired but coma
is rarely observed.

2.3 Diagnosis

Diagnosis of phenytoin poisoning is clinical and based
on history of overdose and/or access to phenytoin and the
presence of specific clinical features especially nystagmus,
dysarthria and ataxia. The diagnosis may be confirmed in the
laboratory by measurement of an elevated serum phenytoin
level but the levels do not always correlate precisely with
the clinical severity of the intoxication.

Been there done that but still have to fight off Neurologist from giving her a loading dose for seizure caused from antibiotics most of the time all because they don't know any better, and who am I.
She was unable to walk for years until she stopped taking this.
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Warpy Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Jan-07-09 02:33 PM
Response to Original message
1. Nystagmus and ataxia are common with overdose
Loading dose is titrated to weight in children. Constant serum level is monitored to make sure therapeutic range is achieved.

Seizures are serious things. The side effect of seizures can be death.

Dilantin and other anticonvulsants do have a list of normal side effects that would discourage anyone from exploring them for recreational use. However, they can be necessary, life saving drugs.

Please listen to the physician. Dr. Google will always let you down.
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bonito Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Jan-07-09 02:56 PM
Response to Reply #1
2. It never prevented a seizure
The incidence of occurrences was even less when she went off of it. Seizure activity can happen when levels drop or rise quickly, also seizure activity was almost always when some antibiotics were introduced regardless, and were always quickly resolved with Lorazepam while on or off the med.

Note also in the information that serum levels don't always correspond with toxic effects.

Listening to the physician can be deadly when they really don't know any better. Dr. Experience is your friend.
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sakabatou Donating Member (1000+ posts) Send PM | Profile | Ignore Tue Apr-14-09 04:13 AM
Response to Original message
3. My doc took me off Dilatin
for what it did to my gums.
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