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as you call it, the reason for the buzzing has to do with a vibrating string hitting a fret, or frets, further down the fretboard. This is usually solved with neck and/or bridge adjustments.
Some details were left out. You said when you play 'some' notes on the low E string, are these on the lower end or higher end of the fretboard, or are they just at random? Do you notice any patterns when this happens? Could they be happening when doing some string bending? What gauge strings are on the instrument?
Just very recently I traded a near-mint Epiphone Les Paul for another instrument and some unfinished wood guitar bodies. My issue with the guitar was never, ever the sound/tone of the instrument or how it felt playing it. It sounded great and played very well. A few tweaks and I had quite the respectable instrument. The balance and bulk of Les Paul were a problem. I found it somewhat uncomfortable to play. Thus, my preference for Strats and Teles.
I did do one thing that I though went a huge distance in improving the instrument. I don't know how what kind of quality control Epiphone uses when making its pickups but I am willing to bet they are not on par with real American made Gibson Les Pauls. After all, Epiphone's purpose is to be the lower cost alternative to Gibson. I did change out the stock humbuckers with a set of aftermarket humbuckers. Specifically, the stock Epiphone pickups were switched with a set of Rio Grande humbuckers. The Rio Grandes are faithful remakes of old Gibson PAFs. Not only that I was able to have installed a coil tap that allowed me to split the bridge pickup into a single coil mode. Supposedly, this was the way Jimmy Page had his Les Pauls wired up.
Anyway, I found the difference to be stunning. Maybe that's it, it could have something to do with the magnets in the pickups. Give that some consideration, investing in a quality set of pickups and a wiring kit, and take it to a good guitar tech. Dimarzio, Seymour Duncan, Rio Grande, Gibson, Lindy Fralin, they all make good stuff. It may cost you some but you may find it well worth it and it may help your string buzz problem.
My two cents, anyway.
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