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"feel pretty good, grey cloud NOT hanging around" - that's great!
Here's what happened with me. Was on it since 2004, max dosage 150 mg. Very tough year, dad dying, mom w/ alz, all kinds of drama and crises with the family business, etc., no siblings to help with any of this. All was good (depression/anxiety-wise) for a long time but then I started to lose motivation & interest. Seemed like depression but I didn't feel sad, just didn't care. Upped dosage, no difference. Doc passed away unexpectedly. Dropped dosage back down (gradually) to 75mg as I started to suspect the Effexor. Talked to a new doc who agreed that it could be hard to distinguish depression sx vs. drug effects. Dropped down to 37.5mg and stayed there for at least a year, then to every other day. Some better, but still not quite myself. In January, started on Prozac 10 mg daily along with Effexor 37.5 (QOD) for two weeks and then stopped the Effexor but kept on the Prozac. All was good as far as the physical stuff - brain zings, etc. - but what surprised me was this: about 7 - 10 days OFF the Effexor, I thought I was in the clear but then I had a bout of EXTREME irritability, really on edge and (fortunately!) not at all "ME". I upped the Prozac to 20 just for those few days, the edginess subsided & now I'm good.
Probably more than you wanted to know, but I hope it helps. I'd talk to doc & try something more benign if I were you. I'm not brave enough to go natural at this point. Maybe you'd be okay with that.
Let me know how it goes & best of luck. I was READY to get off.
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