At the 1997 LDF conference, a study was presented using naïve beagles as subjects. In this study, three groups of six beagles were studied. One group of six was infected; using infected ticks, and treated with four weeks of amoxicillin. Another group was infected and treated with a double dose of doxycycline for four weeks.
The third group was the control. In the doxycycline treated group, at three months post-treatment, it appeared that 100% were cured. But, at two years at autopsy, five of the six (5/6) beagles were shown to have active infection, or complete relapse. The key to uncovering the high incidence of relapse was a long, two-year followup period. The current study cited by the ACP totally ignored this experience showing the necessity of long followup periods, and the fallibility of antibody serologies used as end points to treatment, or as a measure of affecting a cure.
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