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and can either manifest centrally or peripherally. Central ALS is the more serious form and affects the muscles of swallowing, breathing, coughing, and gagging. Such patients have a poor prognosis and a rapid course of the disease ending in death.
The peripheral type, what Stephen Hawking has, starts with voluntary skeletal muscles and proceeds inward. The course is much longer but the end result is the same.
Clearly you have some questions about your uncle's diagnosis. If you are involved with his care, talk directly to his doctors. If you're not, suggest it to someone who is. His rapid weight loss could be connected to an inability to swallow and it could be due to ALS.
I lost a cousin to ALS last summer. Hers started centrally and the progression from diagnosis to death was six months.
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