(Bold emphasis mine.)
While it is indeed a sedative, it has been reported to produce euphoria (the pleasant feelings of well-being most often associated with morphine and other opioids) in some people who have procured it for the purposes of clandestine use.
The potential risk is from
"propofol-related infusion syndrome" - it can produce an elevation in body temperature that is usually not fatal (not "true" malignant hyperthermia as with the rare but fatal side effect of some inhaled anesthetics) but can trigger muscle breakdown called rhabdomyolysis, a rare but devastating side effect that can also occur with statin cholesterol-lowering drugs.
An excellent and timely review of propofol-related infusion syndrome was published in the May issue of Pharmacotherapy by Dr Stephanie Mallow-Corbett and colleagues from the University of Houston College of Pharmacy. The article is reprinted at Medscape (available with free registration). Most notable in this review is that while the syndrome is rare, it is fatal in 64% of cases when it does occur.
However, most relevant to the Jackson case is that propofol can cause cardiac tachyarrhythmias (rhythmic disturbances at high heart rate), especially in people predisposed to cardiac problems.
However - and please note - that while all of my pharmacology/toxicology discussion is based in science and medicine, any extrapolation to the Michael Jackson case and the cause of his death is speculation at this point. I only have access to the reports regarding his potential drug exposure that all of you do. Only time will tell what is the truth once the full autopsy and toxicology reports are released.
Read more hereAbout the blogger And remember this
Related ABC News article?
Flu-like symptoms (chills, fever, body aches) have been reported for up to 3 days following receiving medication; contact prescriber if symptoms occur
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Propofol-related infusion syndrome (PRIS): PRIS is a serious side effect with a high mortality rate characterized by dysrhythmia (eg, bradycardia or tachycardia), heart failure, hyperkalemia, lipemia, metabolic acidosis, and/or rhabdomyolysis or myoglobinuria with subsequent renal failure. Risk factors include poor oxygen delivery, sepsis, serious cerebral injury, and the administration of high doses of propofol (usually doses >83 mcg/kg/minute or >5 mg/kg/hour for >48 hours), but has also been reported following large dose, short-term infusions during surgical anesthesia. The onset of the syndrome is rapid, occurring within 4 days of initiation.