http://www.wired.com/magazine/2011/04/ff_vasectomy/The procedure is known by the clunky acronym RISUG (for reversible inhibition of sperm under guidance), but it is in fact quite elegant: The substance that Das injected was a nontoxic polymer that forms a coating on the inside of the vas. As sperm flow past, they are chemically incapacitated, rendering them unable to fertilize an egg.
If the research pans out, RISUG would represent the biggest advance in male birth control since a clever Polish entrepreneur dipped a phallic mold into liquid rubber and invented the modern condom. “It holds tremendous promise,” says Ronald Weiss, a leading Canadian vasectomy surgeon and a member of a World Health Organization team that visited India to look into RISUG. “If we can prove that RISUG is safe and effective and reversible, there is no reason why anybody would have a vasectomy.”
But here’s the thing: RISUG is not the product of some global pharmaceutical company or state-of-the-art government-funded research lab. It’s the brainchild of a maverick Indian scientist named Sujoy Guha, who has spent more than 30 years refining the idea while battling bureaucrats in his own country and skeptics worldwide. He has prevailed because, in study after study, RISUG has been proven to work 100 percent of the time. Among the hundreds of men who have been successfully injected with the compound so far in clinical trials, there has not been a single failure or serious adverse reaction. The procedure is now in late Phase III clinical trials in India, which means approval in that country could come in as little as two years.
But RISUG is garnering interest beyond India. Every week, Guha’s inbox fills with entreaties from Western men. They’ve heard about RISUG on Internet forums or from occasional mentions in newspaper and magazine articles. Some of them even volunteer to travel to India, offering themselves as lab rats. Guha puts them off gently but politely; for now, the trials are open only to Indian men. Everyone else has to wait. “Our options suck,” fumes one frustrated correspondent, a Florida real estate manager who emailed Guha a few years ago. “I’d gladly put my balls on the chopping block for the benefit of mankind.”